I know the difference between sadness and depression. Clinical depression has no source from which it springs-it just is. Intractable sadness has nothing to do with synapses, or brain chemistry, or essential salts, it's born of something. It's the product of injustice and helplessness. It can be anesthetized, I suppose, but it's there, unaltered, when the medication wears off, like an intruder who has broken into your house and is still there every morning when you wake up.Given the choice, I would rather be depressed. I've come back from depression.