Andrew Solomon Quote
The cumulative results of the brain’s chemical effects are not well understood. In the 1989 edition of the standard Comprehensive Textbook of Psychiatry, for example, one finds this helpful formula: a depression score is equivalent to the level of 3-methoxy-4-hydroxyphenylglycol (a compound found in the urine of all people and not apparently affected by depression); minus the level of 3-methoxy-4-hydroxymandelic acid; plus the level of norepinephrine; minus the level of normetanephrine plus the level of metanepherine, the sum of those divided by the level of 3-methoxy-4-hydroxymandelic acid; plus an unspecified conversion variable; or, as CTP puts it: D-type score = C1 (MHPG) - C2 (VMA) + C3 (NE) - C4 (NMN + MN)/VMA + C0. The score should come out between one for unipolar and zero for bipolar patients, so if you come up with something else—you’re doing it wrong.
The cumulative results of the brain’s chemical effects are not well understood. In the 1989 edition of the standard Comprehensive Textbook of Psychiatry, for example, one finds this helpful formula: a depression score is equivalent to the level of 3-methoxy-4-hydroxyphenylglycol (a compound found in the urine of all people and not apparently affected by depression); minus the level of 3-methoxy-4-hydroxymandelic acid; plus the level of norepinephrine; minus the level of normetanephrine plus the level of metanepherine, the sum of those divided by the level of 3-methoxy-4-hydroxymandelic acid; plus an unspecified conversion variable; or, as CTP puts it: D-type score = C1 (MHPG) - C2 (VMA) + C3 (NE) - C4 (NMN + MN)/VMA + C0. The score should come out between one for unipolar and zero for bipolar patients, so if you come up with something else—you’re doing it wrong.
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About Andrew Solomon
Solomon's book The Noonday Demon: An Atlas of Depression won the 2001 National Book Award, was a finalist for the 2002 Pulitzer Prize, and was included in The Times list of one hundred best books of the decade. Honors awarded to Far from the Tree: Parents, Children, and the Search for Identity include the 2012 National Book Critics Circle Award, the Media for a Just Society Award of the National Council on Crime and Delinquency, the Anisfield-Wolf Book Award, the Dayton Literary Peace Prize, the J. Anthony Lukas Book Prize, and the Wellcome Book Prize.
Solomon is a professor of clinical psychology at Columbia University Medical Center, a lecturer at Yale School of Medicine, and a past President of PEN American Center.